Division of
EMERGENCY MEDICINE
University of Colorado Denver
School of Medicine
Verlyn "Pete" M. Peterson, MD
Associate Professor of Surgery
Division of Emergency Medicine
back to Faculty
Education:
University of Kansas, Lawrence, KS; BS; 1962-1967; Microbiology and
Chemistry
Northwestern University Medical School, Chicago, IL; MD; 1967-1971;
Medicine
Northwestern University McGraw Medical Center, Chicago, IL;
Residency; 1971-1974; Internal Medicine
University of Colorado Health Sciences Center, Denver, CO; Fellowship;
1974-1976; Hematology
Research Interests and Areas of Expertise:
Studies of neutrophil function after major injuries (burn and trauma)
Studies of neutrophil production after major injuries
Identification of novel predictive markers of outcome after major injuries
Implementation of electronic medical record system prompts, triggers,
and passive surveillance to improve patient care in ambulatory care
settings
Selected Publications:
PETERSON VM, Hansbrough J, Buerk C, Rundus C, Wallner S, Smith H, Robinson WA: Regulation of granulopoiesis following severe thermal injury. J Trauma 1983; 23:19‑24
PETERSON VM, Robinson WA, Rundus C, Hansbrough JF: Granulocyte stem cells are decreased in humans with fatal burns. J Trauma 1985; 25:413‑18
Iyengar V, PETERSON VM, Rundus C, Robinson WA: Postburn serum inhibits in vitro production of colony‑stimulating factor by mononuclear peripheral blood cells. Int J Cell Cloning 1986; 4:472-82
Stork LC, PETERSON VM, Rundus CH, Robinson WA: A role for interleukin-1 in the regulation of granulopoiesis. Exp Hematol 1988; 16:163-67
PETERSON VM, Murphy J, Haddix T, Ford P, Anderson SJ, Bartle EJ: Identification of novel prognostic indicators in burned patients. J Trauma 1988; 28:632-37
PETERSON VM, Ambruso DR, Emmett M, Bartle EJ: Inhibition of colony-stimulating factor (CSF) production by postburn serum: Negative feedback inhibition mediated by lactoferrin. J Trauma 1988; 28:632-37
PETERSON VM, Moore EE, Jones TN, Rundus C, Emmett M, Moore FA, McCroskey BL, Haddix T, Parsons PE: Total enteral nutrition versus total parenteral nutrition following major torso injury: Attenuation of hepatic protein reprioritization. Surgery 1988; 104:199-207
Moore FA, PETERSON VM, Moore EE, Rundus C, Poggetti R: Inadequate granulopoiesis after major torso trauma: A hematopoietic regulatory paradox. Surgery 1990; 108:667-75
Moore FA, Moore EE, Poggetti R, McAnena OJ, PETERSON VM, Abernathy CM, Parsons PE: Gut bacterial translocation via the portal vein: A clinical perspective with major torso trauma. J Trauma 1991; 31:629-38
PETERSON VM, Madonna GS, Vogel SN: Differential myelopoietic responsiveness of BALB/C (Itys) and C.D2N24 (Ityr) mice to LPS administration and Salmonella typhimurium infection. Inf Immun 1992; 60:1375-84
Koike K, Moore FA, Moore EE, PETERSON VM, Carl V, Banerjee A: Endotoxin preconditioning preempts gut ischemia/reperfusion-induced neutrophil-mediated lung injury. Surg Forum 1992;43:56-58
Koike K, Moore FA, Moore EE, Trew CE, Banerjee A, PETERSON VM: Endotoxin pretreatment inhibits neutrophil proliferation and function. J Surg Res 1994; 57:49-54.
PETERSON,VM, Adamovicz JJ, Elliott TB, Moore MM, Madonna GS, Jackson WE, Ledney GD, Gause, WC: Gene expression of hematoregulatory cytokines is elevated endogenously following sublethal gamma-irradiation and is differentially enhanced by therapeutic administration of biological response modifers. J Immunol 1994; 153:2321-30
Fontes B, Moore FA, Moore EE, Koike K, Kim FJW, Trew CE, PETERSON VM: Gut ischemia induces bone marrow failure and increases risk of infection. J Surg Res 1994; 57:505-9
Chudgar UH, Rundus CH, PETERSON VM: Recombinant human interleukin-1 receptor antagonist protects myeloid progenitors in a murine model of cyclophosphamide-induced myelotoxicity. Blood 1995; 85:2393-2401
Botha AJ, Moore FA, Moore EE, Fontes B, Banerjee A, PETERSON VM: Postinjury neutrophil priming and activation states: Therapeutic challenges. Shock 1995; 3:157-66
Botha AJ, Moore FA, Moore EE, Kim FJ, Banerjee A, PETERSON VM: Early postinjury neutrophil (PMN) priming and activation: A vulnerable window. Surgery 1995; 118:358-64
Botha AJ, Moore FA, Moore EE, Sauaia A, Banerjee A, PETERSON VM: Postinjury neutrophil sequestration: An early pathogenic mechanism for multiple organ failure. J Trauma 1995; 39:411-17
Biffl WL, Moore FA, Carl VS, Moore EE, Banerjee A, PETERSON VM: Interleukin-6 delays neutrophil apoptosis. Arch Surg 1996; 131:24-30
Chudgar UH, Rundus CH, PETERSON VM: Recombinant human interleukin-1 receptor antagonist protects myeloid progenitors in a murine model of cyclophosphamide-induced myelotoxicity. Blood 1995; 85:2393-2401
Moore FA, Moore EE, PETERSON VM: Inflammatory models of multiple organ failure. Trauma Quarterly 1996;13:
Biffl WL, Moore EE, Moore FA, Barnett CC, Jr, Silliman CC, PETERSON VM: Interleukin-6 stimulates neutrophil production of platelet-activating factor. J Leuk Biol 1996; 59:569-74
Botha AJ, Moore FA, Moore EE, PETERSON VM, Silliman CC, Goode AW: Sequential systemic platelet-activating factor and interleukin-8 primes neutrophils in patients with trauma at risk of multiple organ failure. Br J Surg 1996; 83:1407-12
Rosenthal J, Thurman GW, Cusack N, PETERSON VM, Malech HL, Ambruso DR: Neutrophils from patients after burn injury express a deficiency of the oxidase components p47-phox and p67-phox. Blood 1996; 88:4321-29
Biffl WL, Moore EE, Moore FA, PETERSON VM: Interleukin-6 in the injured patient: Marker of injury or mediator of inflammation? Ann Surg 1996; 224:647-64 Press.
Botha, A.J., Moore, F.A., Moore, E.E., PETERSON, V.M., Goode, A.W.: Base deficit after major trauma directly relates to neutrophil CD11b expression: A proposed mechanism of shock-induced organ injury. Intensive Care Med 1997;
Pellegrin K, PETERSON VM, Rundus CH, Wang XW, Hartford CE: Admission postburn serum IL-6 levels predict subsequent bacteremic sepsis. Surg Forum 1997.
Pellegrin, K. Neurauter, G., Wirleitner, B., Fleming, A.W., PETERSON, V.M., Fuchs, D.: Enhanced enzymatic degradation of tryptophan by indoleamine (2,3)-dioxygenase contributes to the tryptophan deficient state seen after major trauma. Shock 2005; In press.
